Using fluid bed granulation to improve the dissolution of poorly water-soluble drugs

soluplus®; a novel excipient to improve dissolution rate of poorly water soluble drug, celecoxib

Continuous twin-screw granulation for enhancing the dissolution of poorly water soluble drug.

The article describes the application of a twin-screw granulation process to enhance the dissolution rate of the poorly water soluble drug, ibuprofen (IBU). A quality-by-design (QbD) approach was used to manufacture IBU loaded granules via hot-melt extrusion (HME) processing. For the purpose of the study, a design of experiment (DoE) was implemented to assess the effect of the formulation compo...

Technologies to Improve the Solubility, Dissolution and Bioavailability of Poorly Soluble Drugs

Submit Manuscript | http://medcraveonline.com based formulations are filled into hard or soft gelatin capsules. Drugcyclodextrin inclusion complexes are generally prepared by Coprecipitate and Spray drying methods. A number of poorly soluble drugs have been successfully introduced to the market by using new technologies. Among the available technologies, solid dispersion formulations and lipid ...

Technologies to Improve the Solubility, Dissolution and Bioavailability of Poorly Soluble Drugs

Submit Manuscript | http://medcraveonline.com based formulations are filled into hard or soft gelatin capsules. Drugcyclodextrin inclusion complexes are generally prepared by Coprecipitate and Spray drying methods. A number of poorly soluble drugs have been successfully introduced to the market by using new technologies. Among the available technologies, solid dispersion formulations and lipid ...

Improvement of dissolution property of poorly water-soluble drug by supercritical freeze granulation.

The dissolution property of the poorly water-soluble drug, flurbiprofen (FP) was improved by a novel supercritical freeze granulation using supercritical carbon dioxide. Supercritical freeze granulation was defined as a production method of the granulated substances by using the dry ice to generate intentionally for the rapid atomization of the supercritical carbon dioxide to the atmospheric pr...